What Different Types Of Ms Are There

By | October 8, 2024

What Different Types Of Ms Are There – For your patients. What are the different types of MS? – Everyone has their own potential disease course

By Darcy Lewis, contributing writer, MedPage reviewed today Jacqueline A. By Nicholas, MD, MPH, System Director, Neuroimmunology and Multiple Sclerosis, Ohio Health Multiple Sclerosis Center, Columbus

What Different Types Of Ms Are There

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease that attacks the central nervous system (CNS). These attacks lead to the breakdown of myelin, the protective covering that protects nerve fibers in the central nervous system.

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Scar tissue forms at the sites of these failures, which can prevent the central nervous system from communicating with the rest of the body. When this happens, you may lose functionality over time.

MS symptoms can come and go, sometimes without treatment. There is often a lot of variation over time with the same diagnosis and even within the same person.

MS is an unpredictable disease. If you’ve been diagnosed with MS, it’s normal to wonder how your disease will progress.

The first time you experience any of the symptoms of MS, such as blurred vision, muscle weakness, or a “pins and needles” sensation, your doctor will likely describe the episode as an example of clinically isolated syndrome (CSI).

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The next step will be an MRI scan to see if there are any signs of scarring in your brain or spinal cord. Your doctor may also discuss medication, although it is too early to make a formal diagnosis of MS.

This is because a diagnosis of MS usually requires at least two attacks of neurological symptoms, at least a month apart, as well as MRI evidence of central nervous system scarring.

Not everyone with CIS goes on to develop MS. If an MRI done at the time of MS shows brain lesions typically seen in MS, you are much more likely to develop MS over time. If your MRI shows no scarring even though you have neurological symptoms, you are less likely to develop MS.

Relapsing-remitting MS is the most common type of MS, with about 85% of people with it initially receiving this diagnosis. When you have periods with neurological symptoms that come on gradually over hours to days and last more than 24 hours in the absence of fever or infection, it’s called a relapse. Remission refers to improvement in symptoms.

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People usually do well in remission, which can last weeks, months or even years, says Lindsay Ross, MD, of the Cleveland Clinic’s Melle Center for Multiple Sclerosis Treatment and Research. “There may be some residual symptoms even in remission, but there is a general pattern of relapse and decline.”

Just as the course of MS varies from person to person, symptoms can change from day to day or even hour to hour. But just because symptoms may flare up doesn’t mean a new relapse has started. “The symptom has to be new and last more than 24 hours for us to think it’s a relapse,” explained Sammita Satyanarayan, MD, of the Icahn School of Medicine at Mount Sinai in New York.

Over time, some people with relapsing-remitting MS will progress to secondary progressive MS, which means that a person’s functioning gets progressively worse over time in addition to relapses. The disease develops more steadily than in relapsing-remitting disease, and the familiar cycle of relapse and recovery often turns into a more permanent progression of the disease.

“If a patient’s disease begins with an acute attack or relapse, we will begin to label it as relapsing-remitting disease. But then if it starts to lose capacity over time, then we’d say they have secondary progressive disease.” Ross said: “You technically can’t go from relapsing-remitting to progressive primary, but you can go from secondary to progressive disease.”

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People who do not have relapses have an increase in baseline MS. Their symptoms gradually worsen over time. About 10% of people with MS have this diagnosis.

“It’s easy for patients to imagine that their loss of function will continue at the same rate and that they’ll end up in a wheelchair at some point, but that’s often not the case,” says Satyanarayan. “Instead, there may be periods when symptoms stabilize, sometimes for a long time, before they worsen again.”

Radiologically isolated syndrome (RIS) is not currently considered a disease course of MS, although this may change in the future. The term describes a person whose MRI shows brain or spinal cord lesions characteristic of MS, even though there are no previous or current symptoms of MS.

RIS is often diagnosed when a person gets an MRI for another condition, perhaps because they have a bad headache or have been in a car accident. There are currently no treatment guidelines for RIS.

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In 2020, a global study that followed people with RIS for 10 years found that about half developed MS.

Many people with MS ask their doctor what they can expect from the disease in the future. Unfortunately, there is no easy answer to that question.

“We’re pretty good these days at looking at large groups of people and predicting what the average level of disability for the group might be in 5 or 10 years,” says Kevin Patel, MD, of UCLA Health in Los Angeles. “But it’s very difficult to predict an individual’s prognosis over time.”

Certain factors appear to increase the chance of poor individual outcomes, Ross noted. “If someone has more damage in the spinal cord than in the brain, it’s harder to compensate in practice. Or someone who relapses very quickly after diagnosis has a lot of inflammation, which can lead to worse outcomes. , but it is not universal.”

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Medical Journeys is a physician-reviewed collection of clinical resources designed for physicians and other healthcare professionals, as well as the patients they serve. Each chapter of this journey through the disease state includes a physician’s guide and a downloadable/printable patient resource. Medical Journeys follows the path of doctors and patients every step of the way and provides ongoing resources and support as the care team navigates the disease process. Multiple sclerosis (MS) is one of the most common disabling neurological conditions in young adults worldwide.

You can develop MS at any age, but most people are diagnosed between the ages of 20 and 50.

There are advanced forms of MS that are relapsing and progressive, but the course is rarely predictable. Researchers do not fully understand the cause of MS or why it is so difficult to determine the rate of progression.

Recent findings from the MS National Society estimate that nearly one million people in the United States are living with MS. This is more than double the last reported number and the first national survey of MS prevalence since 1975.

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People live with MS all over the world. Approximately 200 new cases are diagnosed each week in the United States, according to the MS Discovery Forum.

MS levels are generally higher further away from the equator. Some researchers consider vitamin D deficiency as a possible explanation.

, people with relatively higher levels of vitamin D are less likely to develop MS. Those who develop MS are more likely to have a less severe case.

People of Northern European descent have the highest risk of developing MS, regardless of where they live. While the lowest risk appears to be in people of Native American, African, and Asian descent.

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Children can also get MS. About 5,000 children and adolescents are currently living with MS in the United States, and about 10,000 children are living with it worldwide, according to the National MS Society.

People with biological relatives who have MS also have a higher risk of developing the condition. Researchers assess heritability, or the ability to inherit MS

, tens to hundreds of gene variations can combine to create a genetic predisposition to develop MS.

Greater chance of developing the condition than the general population. In identical twins, if one twin has MS, there is a 1 in 4 chance that the other twin will also have the disease.

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Researchers and neurologists cannot say exactly what causes MS. The ultimate cause of MS is damage to the myelin, nerve fibers, and neurons in the brain and spinal cord. Together these make up the central nervous system.

Researchers hypothesize that a combination of genetic and environmental factors are at play, but it is not fully understood how.

The relationship between the immune system and the brain can be considered guilty. Researchers hypothesize that the immune system may mistake normal brain cells for foreign ones.

People at high risk of developing MS have brain lesions that can be detected by magnetic resonance imaging (MRI). Those with brain lesions have a 60-80% chance of being diagnosed with MS within a few years, according to the National MS Society.

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Low-risk people, meanwhile, have no brain lesions detected by MRI. They have a 20% chance of being diagnosed with MS during the same period.

RRMS is characterized by well-defined relapses of high disease activity and

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